Patrick M. Woster, Ph.D.

Cofounder & Chief Executive Officer

Dr. Patrick M. Woster received a B.S. in Pharmacy from the University of Nebraska Medical Center in 1978, and a Ph.D. in Medicinal Chemistry from the University of Nebraska in 1986. Following postdoctoral work in chemistry at Rensselaer Polytechnic Institute (1986), and in medicinal chemistry at the University of Michigan (1987), he joined the Wayne State University Faculty of Pharmacy in 1988. From 1988 to 2011, he served as Professor of Medicinal Chemistry in the Department of Pharmaceutical Sciences at Wayne State University in Detroit, MI. In 2011, he moved to the Medical University of South Carolina, where he was appointed Professor and SmartState™ Endowed Chair in Drug Discovery. He also serves as Director of the MUSC Drug Discovery Core., and in 2015 he was appointed Chair of the Department of Drug Discovery and Biomedical Sciences. Over the past 28 years, Dr. Woster’s research has been supported by the National Institutes of Health, the World Health Organization, the Doris Duke Charitable Foundation and several other extramural funding sources. He has authored 128 peer-reviewed manuscripts, 128 scientific abstracts and 18 patent applications outlining his research results. He has also given more than 120 invited and contributed presentations at national and international conferences, organized numerous scientific sessions and served as Chair of the 2009 Gordon Research Conference on Polyamines, and Chair and Organizer of the 2014 National Medicinal Chemistry Symposium. He has been extremely active in the American Chemical Society, and has served as an officer and executive committee member for the Division of Medicinal Chemistry for 25 years, and has just recently been inducted into the ACS hall of fame.

 

 Robert A. Casero, Ph.D.

Cofounder & Chief Information Officer

Dr. Robert A. Casero, Jr. received his B.A. in Biology from Plattsburgh State University (formerly SUNY College at Plattsburgh) in 1976.  After graduation, he served in the United States Army at the Walter Reed Army Institute of Research from 1976-1979 do drug development research on malaria and African sleeping sickness.  While on active duty, he also completed an M.S. in Biology at the George Washington University in 1979.  He earned his Ph.D. in Pharmacology at the State University of New York, at Buffalo, Graduate Division of the Roswell Park Cancer Institute in 1984.  Dr. Casero trained as post-doctoral fellow in the Department of Oncology at the Johns Hopkins University School of Medicine in Baltimore, MD from April of 1984 until he joined the faculty in 1986, where he now is a Professor of Oncology and the Associate Director for Shared Resources of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Since arriving at Hopkins, Dr. Casero’s work has been funded by the National Institutes of Health, the Komen Foundation, the Maryland Cigarette Restitution Fund, and the Samuel Waxman Cancer Research Foundation, among other funding organization.  He has published 201 peer-reviewed papers, served as editor for 4 books on polyamines, published 11 book chapters and editorials, and has published hundreds of abstracts.  He has served on several national and international scientific review committees, reviews for multiple journals, and chaired the 2001 Gordon Research Conference on Polyamines.  Dr. Casero has been an invited speaker at over 50 national and international meeting.  In addition, Dr. Casero has mentored 14 graduate/medical students and 21 post-doctoral fellows, as well as serving on over 60 dissertation committees.  Dr. Casero is a member of the American Association for Cancer Research.

 

Steven L.  Holshouser, Ph.D.

Chief Scientific Officer

Dr. Steven Holshouser is an innovative scientist with an all-inclusive background for the foundations of drug discovery. Through the years, he as gained experience in synthetic chemistry and molecular biology in both the academia and industry setting. He received his BS in Biochemistry and BA in Chemistry at the College of Charleston in Charleston, SC while simultaneously obtaining Summer Undergraduate Research Program (SURP) grants award by the Medical University of South Carolina to develop his skill set in molecular biology. After graduation, Dr. Holshouser furthered his medicinal chemistry skills by maintaining a synthetic chemistry lab, and constructing an in vitro testing facility in order to expedite compound development in-house. Further pursuing his education, he earned his PhD in Drug Discovery and Biomedical Sciences at the Medical University of South Carolina, Charleston, SC. During his training as a PhD student, he took a brief intermission from his studies to work for GlaxoSmithKline where he expanded his medicinal chemistry knowledge by developing compound through physical and computational drug development for the treatment of Chronic Obstructive Pulmonary Disease (COPD). After Graduation, he accepted the position as Head of Discovery for Firststring Research to identify novel uses for a topical wound healing peptide (Granexin©) in phase III clinical trials for diabetic foot ulcers. Currently, Dr. Holshouser is Director of Screening and Lead Optimization at the Medical University of South Carolina’s Drug Core, located in Charleston, SC. His experience in compound screening, synthesis and purification allows him to work on a broad range of projects.